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田锡炜
生物工程专业:硕士生导师
生物学专业:硕士生导师
生物与医药专业(生物工程领域):硕士生导师
田锡炜,男,博士,太阳集团城网址娱网副教授,生物工程专业、微生物学硕士研究生导师。主要从事微生物高通量菌种筛选、代谢改造、发酵过程优化与放大研究。主持国家自然科学青年基金、国家重点研究计划子课题(2项)、中央高校基本业务费青年探索基金、国际知名企业横向课题等科研项目。累计发表SCI论文20多篇,申请中国发明专利4项,授权1项;作为主要完成人获得2018年上海市科技进步二等奖,2019年教育部科技进步二等奖。
教育经历
2009.09-2015.11 suncitygroup太阳新城发酵工程工学博士 导师:储炬教授
2005.09-2009.07 suncitygroup太阳新城生物技术理学学士
工作经历
2018.11-至今suncitygroup太阳新城suncitygroup太阳集团讲师
2016.01-2018.10 suncitygroup太阳新城suncitygroup太阳集团师资博士后
研究方向
1. 生物过程工程,包括乳酸菌、假丝酵母生产化学品优化
2. 高性能菌株筛选,包括高通量细菌、酵母、霉菌筛选平台建立
3. 微生物代谢工程,包括乳酸菌、假丝酵母平台crispr-cas9编辑平台及高性能菌株构建
科研项目
1. 国家自然科学青年基金,基于拟干酪乳杆菌呼吸代谢响应环境高渗应激和氧化应激分析的高浓度乳酸生产研究,31700038,2018.01-2020.12,主持
2. 国家重点研发计划子课题,低成本乳酸、丙交酯和聚乳酸制备关键技术及产业化研究,2017YFB0309302,2017.07-2021.06,主持
3. 中央高校基本业务费青年探索基金,拟干酪乳杆菌响应环境高渗应激作用机理研究及应用,2018.01-2019.12,主持
4. 赢创德固赛(中国)投资有限公司上海分公司,Starmerella bombicola合成槐糖脂,2016.06-2018.01,项目实施负责人
5. 赢创德固赛(中国)投资有限公司上海分公司,高通量筛选Starmerella bombicola获得槐糖脂高产菌株,2016.11-2018.04,项目实施负责人
6. 赢创(上海)投资管理有限公司,连续发酵以及细胞固定化生产槐糖脂,2018.04-2018.12,项目实施负责人。
7. 丰益(上海)生物技术研发中心有限公司,米曲霉生产米黑根毛霉脂肪酶(RML)发酵工艺优化,2018.11-2019.10,项目实施负责人
代表性论文
1. Yang Chen, Yumeng Lin, Xiwei Tian*, Qianhui Li, Ju Chu*. Real-time dynamic analysis with low-field nuclear magnetic resonance of residual oil and sophorolipids concentrations in the fermentation process o Starmerella bombicola. Journal of Microbiological Methods, 2019, 157: 9-15.
2. Zhaopeng Liu, Xiwei Tian*, Yang Chen, Yumeng Lin, Ali Mohsin, Ju Chu*. Efficient sophorolipids production via a novel in situ separation technology by Starmerella bombicola. Process Biochemistry, 2019, 81(6): 1-10.
3. Xiwei Tian, Yonghong Wang, Ju Chu*, Yingping* Zhuang, Siliang Zhang. Metabolite profiling coupled with metabolic flux analysis reveals physiological and metabolic impacts on Lactobacillus paracasei oxygen metabolism. Process Biochemistry, 2018, 68(5): 1-11.
4. Xiwei Tian, Yuting Shen, Yingping Zhuang, Wei Zhao, Haifeng Hang, Ju Chu*. Kinetic analysis of sodium gluconate production by Aspergillus niger with different inlet oxygen concentrations. Bioprocess and Biosystems Engineering, 2018, 41(11): 1697-1706.
5. Xiwei Tian*, Yonghong Wang, Ju Chu, Ali Mohsin, Yingping Zhuang*. Exploring cellular fatty acid composition and intracellular metabolites of osmotic-tolerant mutant for highly efficient lactic acid production. Journal of Biotechnology, 2018, 286(11): 27-35.
6. Xiwei Tian, Yonghong Wang*, Ju Chu*, Yingping Zhuang, Siliang Zhang. Enhanced L-lactic acid production in Lactobacillus paracasei by exogenous proline addition based on comparative metabolite profiling analysis. Applied Microbiology and Biotechnology. 2016, 100: 2301-2310.
7. Xiwei Tian, Yonghong Wang*, Ju Chu*, Yingping Zhuang, Siliang Zhang. Improvement of L-lactic acid production with a two–step OUR control strategy. Journal of Chemical Technology and Biotechnology. 2016, 91: 2496-2502.
8. Xiwei Tian, Ning Zhang, Yi Yang, Yonghong Wang*, Ju Chu*, Yingping Zhuang, Siliang Zhang. The effect of redox environment on L-lactic acid production by Lactobacillus paracasei – A proof by genetically encoded in vivo NADH biosensor. Process Biochemistry. 2015, 50(12): 2029-2034.
9. Xiwei Tian, Yonghong Wang*, Ju Chu*, Yingping Zhuang, Siliang Zhang. Oxygen transfer efficiency and environmental osmolarity response to neutralizing agents on l-lactic acid production efficiency by Lactobacillus paracasei. Process Biochemistry. 2014, 49(12): 2049-2054.
10. Xiwei Tian, Yonghong Wang*, Ju Chu*, Yingping Zhuang, Siliang Zhang. L-Lactic acid production benefits from reduction of environmental osmotic stress through neutralizing agent combination. Bioprocess and Biosystems Engineering. 2014, 37(9): 1917-1923.
联系方式
地址:上海市徐汇区梅陇路130号,实验18楼411室
电话:021-64257019
邮箱:xiweitian@ecust.edu.cn