![](/_upload/article/images/9d/d1/91d59a314481bf9c4888ddba5609/cab37600-96cf-4283-b567-069ebdaf5041.jpg)
欧阳立明
生物学专业:硕士生导师
生物工程专业:硕士生导师
生物与医药专业(生物工程领域):硕士生导师
女,博士,副教授,硕士生导师。
学历及工作经历
2001年suncitygroup太阳新城与军事医学科学院联合培养博士毕业,获生物化工专业博士。
2001年7月起任职于太阳集团城网址娱网应用生物学系,2007年起受聘副教授,2014年起兼任国家生化工程技术研究中心研究人员。2020年9月起加入suncitygroup太阳新城活性天然产物发现与智造研究中心(张立新团队)。现任华理-金城联合研究中心副主任。
2011.8-2012.8 在美国杜克大学生物学系访问一年
2017年在瑞典查尔姆斯理工大学生物工程系访问一年
获奖情况
2009年获suncitygroup太阳新城育英奖一等奖
上海市精品课程《基因组学》主讲人
近年研究方向
主要涉及原核和真核细胞组学数据挖掘、基因表达调控网络、工业微生物菌株的系统代谢工程、微生物遗传转化新技术、酶基因的改造和应用、肿瘤生物学机制和细胞疗法等多学科的交叉领域。曾负责国家自然科学基金,上海市自然科学基金,生物反应器工程国家重点实验室开放课题等纵向课题,目前负责国家重点研发计划合成生物学重点专项子课题和横向研究课题,经费每年百万以上,与企业实践密切结合。课题组学术资源丰富,人才济济。目前在研方向包括工业微生物过程组学、大健康产品细胞工厂代谢工程与过程调控、干细胞过程生物学研究等。欢迎有志青年加入!
近年已发表代表性论著(*为通讯作者,#为共同作者):
1. Hongzhong Lu#, Weiqiang Cao#, Xiaoyun Liu, Yufei Sui, Liming Ouyang*, Jianye Xia, Mingzhi Huang, Yingping Zhuang, Siliang Zhang, Henk Noorman, Ju Chu*. Multi-omics integrative analysis with GEMs simulation reveals global cellular adaptations of Aspergillus niger under industrial enzyme production conditions. Scientific Reports. 2018, 8(1):14404. doi: 10.1038/s41598-018-32341-1.
2. Liming Ouyang; Petter Holland; Hongzhong Lu; David Bergenholm; Jens Nielsen*.
Integrated analysis of the yeast NADPH-regulator Stb5 reveals distinct differences in NADPH requirements and regulation in different states of yeast metabolism. FEMS Yeast Research. 2018, 18(8); DOI:10.1093/femsyr/foy091 (Dec 2018)
3. Yuan Zhang; Liming Ouyang*; Yilin Nan; Ju Chu. Efficient gene deletion and replacement in Aspergillus niger by modified in vivo CRISPR/Cas9 systems. Bioresources and Bioprocessing. 2019, 6:4. DOI: 10.1186/s40643-019-0239-7
4. Yu-fei Sui#; Li-Ming Ouyang (#co-first author); Tabea Schütze; Shu Cheng; Vera Meyer*; Yingping Zhuang*. Comparative genomics of the aconidial Aspergillus niger strain LDM3 predicts genes associated with its high protein secretion capacity. Applied Microbiology and Biotechnology. 2020, 104, 2623–2637. DOI: 10.1007/s00253-020-10398-1
5. Yu-Fei Sui, Tabea Schütze, Li-Ming Ouyang, Hongzhong Lu, Peng Liu, Xianzun Xiao, Jie Qi, Ying-Ping Zhuang*, Vera Meyer*. Engineering cofactor metabolism for improved protein and glucoamylase production in Aspergillus niger. Microbial Cell Factory. 2020, 19(1):198. doi: 10.1186/s12934-020-01450-w.
6. Weiqiang Cao, Guan Wang, Hongzhong Lu, Liming Ouyang*, Ju Chu, Yufei Sui, Yingping Zhuang*. Improving cytosolic aspartate biosynthesis increases glucoamylase production inAspergillus nigerunder oxygen limitation. Microbial Cell Factory. 2020. 19: 81. DOI: 10.1186/s12934-020-01340-1.
7. Yilin Nan; Liming Ouyang*; Ju Chu. In-vitro CRISPR/Cas9 System for Genome Editing of Aspergillus niger Based on Removable Bidirectional Selection Marker AmdS. Biotechnology and Applied Biochemistry. 2021, 68(5):964-970.
8. Yaojun Tong, Nuo Sun, Xiangming Wang, Qi Wei, Yu Zhang, Ren Huang, Yingying Pu, Huanqin Dai, Biao Ren, Gang Pei, Fuhang Song, Guoliang Zhu, Xinye Wang, Xuekui Xia, Xiangyin Chen, Lan Jiang, Jingyu Zhang, Liming Ouyang, Buchang Zhang, Yuanying Jiang, Xueting Liu, Richard Calderone, Fan Bai, Lixin Zhang, Gil Alterovitz. Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p. Science Bulletin. 2021, 66(18): 1895-1905.
9. Xianzun Xiao, Liming Ouyang*, Jie Qi, Ju Chu. Exploration and characterization of hypoxia-inducible endogenous promoters in Aspergillus niger. Applied Microbiology and Biotechnology. 2021. 105, 5529–5539. DOI: 10.1007/s00253-021-11417-5
10. Shanshan Li, Bowen Yang, Gao-Yi Tan, Li-Ming Ouyang, Shiwen Qiu, Weishan Wang*, Wensheng Xiang*, Lixin Zhang*. Polyketide pesticides from actinomycetes. Current Opinion in Biotechnology. 2021, 69: 299-307.
11. Jingyu Zhang, Lan Jiang, Xiangyin Chen, Kangjie Lv, Mostafa Basiony, Guoliang Zhu, Loganathan Karthik, Liming Ouyang, Lixin Zhang, Xueting Liu*. Recent advances in biotechnology for marine enzymes and molecules. Current Opinion in Biotechnology. 2021, 69: 308-315. DOI: 10.1016/j.copbio.2021.05.009
12. Mostafa Basiony, 欧阳立明*, 汪丹妮, 余家明, 周立铭, 朱墨涵, 王徐媛, 冯洁, 戴璟, 沈义杰, 张成国, 花强, 杨修亮, 张立新. Optimization of Microbial Cell Factories for Astaxanthin Production: Biosynthesis and Regulations, Engineering Strategies and Fermentation Optimization Strategies. Synthetic and Systems Biotechnology. 2022, 7(2): 689-704. DOI: 10.1016/j.synbio.2022.01.002
13. 《应用生物化学》(第二版)/十一五教材计划,欧伶,俞建瑛,欧阳立明,李素霞主编. 化工出版社. 2009.2. (ISBN 978-7-122-04348-1)
14. 《基因工程》(第三版)/“十二五”普通高等教育本科国家级规划教材 (张惠展, 欧阳立明, 叶江编著). 高教出版社. 2015.3 (ISBN: 9787040417623).
代表性发明专利:
1. 提高黑曲霉糖化酶生产能力的方法及重组黑曲霉菌株
申请号:CN202110327594.7 申请日期2021-3-26公开号CN113061539A公开日2021-07-02
申请人:suncitygroup太阳新城
作者:欧阳立明,祁洁,隋雨菲,肖贤尊,庄英萍
2. 一种产虾青素的工程菌及其制备方法和应用
申请号:202111596075.7 申请日期:2021.12.24
申请人:suncitygroup太阳新城,金城生物
作者:欧阳立明,戴璟,余家明,张立新,杨修亮,李江涛,张成国,荣金雷,刘敬
3. 抗氧化剂在提高脐带间充质干细胞活力中的应用
申请号:202210277757.X 申请日期:2022.3.16
申请人:北京唐颐惠康生物医学技术有限公司,suncitygroup太阳新城
发明人:欧阳立明,郑兆娟,曹毓琳,张立新
联系方式:
E-mail: ouyanglm@ecust.edu.cn